Injectable nanofibrous spongy microspheres for NR4A1 plasmid DNA transfection to reverse fibrotic degeneration and support disc regeneration

Safe and efficient gene therapy is highly desired for controlling pathogenic fibrosis of nucleus pulposus (NP) tissue, which would result in intervertebral disc (IVD) degeneration and disability if left untreated. In this work, a hyperbranched polymer (HP) with high plasmid DNA (pDNA) binding affini...

Descripción completa

Guardado en:
Detalles Bibliográficos
Publicado en:Biomaterials
Autores principales: Feng, Ganjun, Zhang, Zhanpeng, Dang, Ming, Zhang, Xiaojin, Doleyres, Yasmine, Song, Yueming, Chen, Di, Ma, Peter X.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2017
Materias:
Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5448136/
https://ncbi.nlm.nih.gov/pubmed/28376367
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biomaterials.2017.03.029
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares