Injectable nanofibrous spongy microspheres for NR4A1 plasmid DNA transfection to reverse fibrotic degeneration and support disc regeneration

Safe and efficient gene therapy is highly desired for controlling pathogenic fibrosis of nucleus pulposus (NP) tissue, which would result in intervertebral disc (IVD) degeneration and disability if left untreated. In this work, a hyperbranched polymer (HP) with high plasmid DNA (pDNA) binding affini...

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Dades bibliogràfiques
Publicat a:Biomaterials
Autors principals: Feng, Ganjun, Zhang, Zhanpeng, Dang, Ming, Zhang, Xiaojin, Doleyres, Yasmine, Song, Yueming, Chen, Di, Ma, Peter X.
Format: Artigo
Idioma:Inglês
Publicat: 2017
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5448136/
https://ncbi.nlm.nih.gov/pubmed/28376367
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biomaterials.2017.03.029
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