Injectable nanofibrous spongy microspheres for NR4A1 plasmid DNA transfection to reverse fibrotic degeneration and support disc regeneration

Safe and efficient gene therapy is highly desired for controlling pathogenic fibrosis of nucleus pulposus (NP) tissue, which would result in intervertebral disc (IVD) degeneration and disability if left untreated. In this work, a hyperbranched polymer (HP) with high plasmid DNA (pDNA) binding affini...

Полное описание

Сохранить в:
Библиографические подробности
Опубликовано в: :Biomaterials
Главные авторы: Feng, Ganjun, Zhang, Zhanpeng, Dang, Ming, Zhang, Xiaojin, Doleyres, Yasmine, Song, Yueming, Chen, Di, Ma, Peter X.
Формат: Artigo
Язык:Inglês
Опубликовано: 2017
Предметы:
Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5448136/
https://ncbi.nlm.nih.gov/pubmed/28376367
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biomaterials.2017.03.029
Метки: Добавить метку
Нет меток, Требуется 1-ая метка записи!

Схожие документы