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A genetic variant of the sperm-specific SLO3 K(+) channel has altered pH and Ca(2+) sensitivities

To fertilize an oocyte, sperm must first undergo capacitation in which the sperm plasma membrane becomes hyperpolarized via activation of potassium (K(+)) channels and resultant K(+) efflux. Sperm-specific SLO3 K(+) channels are responsible for these membrane potential changes critical for fertiliza...

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Dades bibliogràfiques
Publicat a:J Biol Chem
Autors principals: Geng, Yanyan, Ferreira, Juan J., Dzikunu, Victor, Butler, Alice, Lybaert, Pascale, Yuan, Peng, Magleby, Karl L., Salkoff, Lawrence, Santi, Celia M.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2017
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5448129/
https://ncbi.nlm.nih.gov/pubmed/28377504
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.776013
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