SLO3 K(+) Channels Control Calcium Entry through CATSPER Channels in Sperm

Here we show how a sperm-specific potassium channel (SLO3) controls Ca(2+) entry into sperm through a sperm-specific Ca(2+) channel, CATSPER, in a totally unanticipated manner. The genetic deletion of either of those channels confers male infertility in mice. During sperm capacitation SLO3 hyperpola...

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Vydáno v:J Biol Chem
Hlavní autoři: Chávez, Julio César, Ferreira, Juan José, Butler, Alice, De La Vega Beltrán, José Luis, Treviño, Claudia L., Darszon, Alberto, Salkoff, Lawrence, Santi, Celia M.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2014
Témata:
Signal Transduction
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4231700/
https://ncbi.nlm.nih.gov/pubmed/25271166
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.607556
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