DNA mutagenic activity and capacity for HIV-1 restriction of the cytidine deaminase APOBEC3G depend on whether DNA or RNA binds to tyrosine 315

APOBEC3G (A3G) belongs to the AID/APOBEC protein family of cytidine deaminases (CDA) that bind to nucleic acids. A3G mutates the HIV genome by deamination of dC to dU, leading to accumulation of virus-inactivating mutations. Binding to cellular RNAs inhibits A3G binding to substrate single-stranded...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Polevoda, Bogdan, Joseph, Rebecca, Friedman, Alan E., Bennett, Ryan P., Greiner, Rebecca, De Zoysa, Thareendra, Stewart, Ryan A., Smith, Harold C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2017
Assuntos:
RNA
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5448093/
https://ncbi.nlm.nih.gov/pubmed/28381554
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.767889
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