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RNA toxicity and foci formation in microsatellite expansion diseases

More than 30 incurable neurological and neuromuscular diseases are caused by simple microsatellite expansions consisted of 3–6 nucleotides. These repeats can occur in non-coding regions and often result in a dominantly inherited disease phenotype that is characteristic of a toxic RNA gain-of-functio...

Полное описание

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Библиографические подробности
Опубликовано в: :Curr Opin Genet Dev
Главные авторы: Zhang, Nan, Ashizawa, Tetsuo
Формат: Artigo
Язык:Inglês
Опубликовано: 2017
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5447490/
https://ncbi.nlm.nih.gov/pubmed/28208060
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.gde.2017.01.005
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