Computational Discovery of Niclosamide Ethanolamine, A Repurposed Drug Candidate That Reduces Growth of Hepatocellular Carcinoma Cells in Vitro and in Mice by Inhibiting CDC37 Signaling

BACKGROUND & AIMS: Drug repositioning offers a shorter approval process than new drug development. We therefore searched large public datasets of drug-induced gene expression signatures to identify agents that might be effective against hepatocellular carcinoma (HCC). METHODS: We searched public...

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Vydáno v:Gastroenterology
Hlavní autoři: Chen, Bin, Wei, Wei, Ma, Li, Yang, Bin, Gill, Ryan M., Chua, Mei-Sze, Butte, Atul J., So, Samuel
Médium: Artigo
Jazyk:Inglês
Vydáno: 2017
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5447464/
https://ncbi.nlm.nih.gov/pubmed/28284560
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2017.02.039
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