BDNF Val66Met predicts cognitive decline in the Wisconsin Registry for Alzheimer's Prevention

OBJECTIVE: To examine the influence of the brain-derived neurotrophic factor (BDNF) Val66Met polymorphism on longitudinal cognitive trajectories in a large, cognitively healthy cohort enriched for Alzheimer disease (AD) risk and to understand whether β-amyloid (Aβ) burden plays a moderating role in...

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Gepubliceerd in:Neurology
Hoofdauteurs: Boots, Elizabeth A., Schultz, Stephanie A., Clark, Lindsay R., Racine, Annie M., Darst, Burcu F., Koscik, Rebecca L., Carlsson, Cynthia M., Gallagher, Catherine L., Hogan, Kirk J., Bendlin, Barbara B., Asthana, Sanjay, Sager, Mark A., Hermann, Bruce P., Christian, Bradley T., Dubal, Dena B., Engelman, Corinne D., Johnson, Sterling C., Okonkwo, Ozioma C.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Lippincott Williams & Wilkins 2017
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5447398/
https://ncbi.nlm.nih.gov/pubmed/28468845
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1212/WNL.0000000000003980
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