BDNF Val66Met predicts cognitive decline in the Wisconsin Registry for Alzheimer's Prevention

OBJECTIVE: To examine the influence of the brain-derived neurotrophic factor (BDNF) Val66Met polymorphism on longitudinal cognitive trajectories in a large, cognitively healthy cohort enriched for Alzheimer disease (AD) risk and to understand whether β-amyloid (Aβ) burden plays a moderating role in...

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Publicado en:Neurology
Main Authors: Boots, Elizabeth A., Schultz, Stephanie A., Clark, Lindsay R., Racine, Annie M., Darst, Burcu F., Koscik, Rebecca L., Carlsson, Cynthia M., Gallagher, Catherine L., Hogan, Kirk J., Bendlin, Barbara B., Asthana, Sanjay, Sager, Mark A., Hermann, Bruce P., Christian, Bradley T., Dubal, Dena B., Engelman, Corinne D., Johnson, Sterling C., Okonkwo, Ozioma C.
Formato: Artigo
Idioma:Inglês
Publicado: Lippincott Williams & Wilkins 2017
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5447398/
https://ncbi.nlm.nih.gov/pubmed/28468845
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1212/WNL.0000000000003980
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