Daily Rifapentine for Treatment of Pulmonary Tuberculosis. A Randomized, Dose-Ranging Trial

Rationale: Rifapentine has potent activity in mouse models of tuberculosis chemotherapy but its optimal dose and exposure in humans are unknown. Objectives: We conducted a randomized, partially blinded dose-ranging study to determine tolerability, safety, and antimicrobial activity of daily rifapent...

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Publicado en:Am J Respir Crit Care Med
Main Authors: Dorman, Susan E., Savic, Radojka M., Goldberg, Stefan, Stout, Jason E., Schluger, Neil, Muzanyi, Grace, Johnson, John L., Nahid, Payam, Hecker, Emily J., Heilig, Charles M., Bozeman, Lorna, Feng, Pei-Jean I., Moro, Ruth N., MacKenzie, William, Dooley, Kelly E., Nuermberger, Eric L., Vernon, Andrew, Weiner, Marc
Formato: Artigo
Idioma:Inglês
Publicado: American Thoracic Society 2015
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Original Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5447287/
https://ncbi.nlm.nih.gov/pubmed/25489785
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1164/rccm.201410-1843OC
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