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CHRR: coordinate hit-and-run with rounding for uniform sampling of constraint-based models

SUMMARY: In constraint-based metabolic modelling, physical and biochemical constraints define a polyhedral convex set of feasible flux vectors. Uniform sampling of this set provides an unbiased characterization of the metabolic capabilities of a biochemical network. However, reliable uniform samplin...

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Vydáno v:Bioinformatics
Hlavní autoři: Haraldsdóttir, Hulda S, Cousins, Ben, Thiele, Ines, Fleming, Ronan M.T, Vempala, Santosh
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2017
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5447232/
https://ncbi.nlm.nih.gov/pubmed/28158334
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/bioinformatics/btx052
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