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Sesn2 gene ablation enhances susceptibility to gentamicin-induced hair cell death via modulation of AMPK/mTOR signaling

The process of gentamicin-induced hair cell damage includes the activation of oxidative stress processes. Sestrins, as stress-responsive proteins, protect cells against oxidative stress. Sestrins, particularly Sestrin-2, suppress excessive reactive oxygen species (ROS) accumulation and inhibit mamma...

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Podrobná bibliografie
Vydáno v:Cell Death Discov
Hlavní autoři: Ebnoether, Eliane, Ramseier, Alessia, Cortada, Maurizio, Bodmer, Daniel, Levano-Huaman, Soledad
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2017
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5447131/
https://ncbi.nlm.nih.gov/pubmed/28580173
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddiscovery.2017.24
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