Inhibition of Myeloid Differentiation Factor 88 Reduces Human and Mouse T-Cell Interleukin-17 and IFNγ Production and Ameliorates Experimental Autoimmune Encephalomyelitis Induced in Mice

Myeloid differentiation factor 88 (MyD88) recruits signaling proteins to the intracellular domain of receptors belonging to the toll-like/interleukin-1 (IL-1) receptor superfamily. Mice lacking MyD88 are highly susceptible to infectious diseases, but tend to resist experimentally induced autoimmune...

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Vydáno v:Front Immunol
Hlavní autoři: Dishon, Shira, Cohen, Shmuel J., Cohen, Irun R., Nussbaum, Gabriel
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2017
Témata:
Immunology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5447018/
https://ncbi.nlm.nih.gov/pubmed/28611775
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2017.00615
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