IFN-γ and IL-17 production in Experimental Autoimmune Encephalomyelitis depends on local APC•T cell complement production

IFN-γ and IL-17 producing T cells autoreactive across myelin components are central to the pathogenesis of multiple sclerosis (MS). Using direct in vivo, adoptive transfer, and in vitro systems, here we show that the generation of these effectors in MOG(35–55) induced EAE depends on interactions of...

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Hauptverfasser: Liu, Jinbo, Lin, Feng, Strainic, Michael G., An, Fengqi, Miller, Robert H., Altuntas, Cengiz Z., Heeger, Peter S., Tuohy, Vincent K., Medof, M. Edward
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2008
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3581326/
https://ncbi.nlm.nih.gov/pubmed/18424707
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