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Quantitative analysis of cryptic splicing associated with TDP-43 depletion
BACKGROUND: Reliable exon recognition is key to the splicing of pre-mRNAs into mature mRNAs. TDP-43 is an RNA-binding protein whose nuclear loss and cytoplasmic aggregation are a hallmark pathology in amyotrophic lateral sclerosis and frontotemporal dementia (ALS/FTD). TDP-43 depletion causes the ab...
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| Pubblicato in: | BMC Med Genomics |
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| Autori principali: | , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
BioMed Central
2017
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5446763/ https://ncbi.nlm.nih.gov/pubmed/28549443 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12920-017-0274-1 |
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