Glucagon‐like peptide‐1 receptor signalling reduces microvascular thrombosis, nitro‐oxidative stress and platelet activation in endotoxaemic mice

BACKGROUND AND PURPOSE: Excessive inflammation in sepsis causes microvascular thrombosis and thrombocytopenia associated with organ dysfunction and high mortality. The present studies aimed to investigate whether inhibition of dipeptidyl peptidase‐4 (DPP‐4) and supplementation with glucagon‐like pep...

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Опубликовано в: :Br J Pharmacol
Главные авторы: Steven, Sebastian, Jurk, Kerstin, Kopp, Maximilian, Kröller‐Schön, Swenja, Mikhed, Yuliya, Schwierczek, Kathrin, Roohani, Siyer, Kashani, Fatemeh, Oelze, Matthias, Klein, Thomas, Tokalov, Sergey, Danckwardt, Sven, Strand, Susanne, Wenzel, Philip, Münzel, Thomas, Daiber, Andreas
Формат: Artigo
Язык:Inglês
Опубликовано: John Wiley and Sons Inc. 2016
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Themed Section: Research Paper
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5446582/
https://ncbi.nlm.nih.gov/pubmed/27435156
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.13549
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