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Dynamics and ligand-induced conformational changes in human prolyl oligopeptidase analyzed by hydrogen/deuterium exchange mass spectrometry

Prolyl oligopeptidase (PREP) is conserved in many organisms across life. It is involved in numerous processes including brain function and neuropathology, that require more than its strict proteolytic role. It consists of a seven-bladed β-propeller juxtaposed to a catalytic α/β-hydrolase domain. The...

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Bibliographische Detailangaben
Veröffentlicht in:Sci Rep
Hauptverfasser: Tsirigotaki, Alexandra, Elzen, Roos Van, Veken, Pieter Van Der, Lambeir, Anne-Marie, Economou, Anastassios
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2017
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5446394/
https://ncbi.nlm.nih.gov/pubmed/28550305
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-02550-1
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