Gene delivery of human apolipoprotein E alters brain Aβ burden in a mouse model of Alzheimer's disease

Apolipoprotein E (apoE) alleles are important genetic risk factors for Alzheimer's disease (AD), with the ε4 allele increasing and the ε2 allele decreasing risk for developing AD. ApoE has been shown to influence brain amyloid-β peptide (Aβ) and amyloid burden, both in humans and in transgenic...

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Main Authors: Dodart, Jean-Cosme, Marr, Robert A., Koistinaho, Milla, Gregersen, Beth M., Malkani, Seema, Verma, Inder M., Paul, Steven M.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2005
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC544620/
https://ncbi.nlm.nih.gov/pubmed/15657137
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0409072102
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