Assessing the suitability of summary data for two-sample Mendelian randomization analyses using MR-Egger regression: the role of the [Formula: see text] statistic

Background: MR-Egger regression has recently been proposed as a method for Mendelian randomization (MR) analyses incorporating summary data estimates of causal effect from multiple individual variants, which is robust to invalid instruments. It can be used to test for directional pleiotropy and prov...

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Détails bibliographiques
Publié dans:Int J Epidemiol
Auteurs principaux: Bowden, Jack, Del Greco M, Fabiola, Minelli, Cosetta, Davey Smith, George, Sheehan, Nuala A, Thompson, John R
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2016
Sujets:
Mendelian Randomisation and Instrumental Variable Analysis
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5446088/
https://ncbi.nlm.nih.gov/pubmed/27616674
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/ije/dyw220
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