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Processing of Alzheimer beta/A4 amyloid precursor protein: modulation by agents that regulate protein phosphorylation.

The turnover and processing of the Alzheimer beta/A4 amyloid precursor protein (beta APP) has been studied in PC12 cells after treatment with agents that regulate protein phosphorylation. Phorbol 12,13-dibutyrate, an agent that stimulates protein kinase C, decreased the levels of mature beta APP and...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Buxbaum, J D, Gandy, S E, Cicchetti, P, Ehrlich, M E, Czernik, A J, Fracasso, R P, Ramabhadran, T V, Unterbeck, A J, Greengard, P
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1990
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC54458/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2116015/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.87.15.6003
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