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Optimizing complex phenotypes through model-guided multiplex genome engineering
We present a method for identifying genomic modifications that optimize a complex phenotype through multiplex genome engineering and predictive modeling. We apply our method to identify six single nucleotide mutations that recover 59% of the fitness defect exhibited by the 63-codon E. coli strain C3...
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| Publicado no: | Genome Biol |
|---|---|
| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BioMed Central
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5445303/ https://ncbi.nlm.nih.gov/pubmed/28545477 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-017-1217-z |
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