The role of S1PR2 in bile acid-induced cholangiocyte proliferation and cholestasis-induced liver injury in mice

Bile duct obstruction is a potent stimulus for cholangiocyte proliferation, especially for large cholangiocytes. Our previous studies reported that conjugated bile acids (CBAs) activate the AKT and ERK1/2 signaling pathways via the sphingosine 1-phosphate receptor 2 (S1PR2) in hepatocytes and cholan...

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Foilsithe in:Hepatology
Main Authors: Wang, Yongqing, Aoki, Hiroaki, Yang, Jing, Peng, Kesong, Liu, Runping, Li, Xiaojiaoyang, Qiang, Xiaoyan, Sun, Lixin, Gurley, Emily C, Lai, Guanhua, Zhang, Luyong, Liang, Guang, Nagahashi, Masayuki, Takabe, Kazuaki, Pandak, William M, Hylemon, Phillip B., Zhou, Huiping
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2017
Ábhair:
Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5444993/
https://ncbi.nlm.nih.gov/pubmed/28120434
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.29076
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