Coronary Artery Disease–Associated LIPA Coding Variant rs1051338 Reduces Lysosomal Acid Lipase Levels and Activity in Lysosomes

OBJECTIVE—: Genome-wide association studies have linked variants at chromosome 10q23 with increased coronary artery disease risk. The disease-associated variants fall in LIPA, which encodes lysosomal acid lipase (LAL), the enzyme responsible for lysosomal cholesteryl ester hydrolysis. Loss-of-functi...

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Detalhes bibliográficos
Publicado no:Arterioscler Thromb Vasc Biol
Main Authors: Morris, Gavin E., Braund, Peter S., Moore, Jasbir S., Samani, Nilesh J., Codd, Veryan, Webb, Tom R.
Formato: Artigo
Idioma:Inglês
Publicado em: Lippincott Williams & Wilkins 2017
Assuntos:
Basic Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5444428/
https://ncbi.nlm.nih.gov/pubmed/28279971
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.116.308734
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