Impact of Mucositis on Absorption and Systemic Drug Exposure of Isavuconazole

Isavuconazonium sulfate is the water-soluble prodrug of isavuconazole. Population analyses have demonstrated relatively predictable pharmacokinetic (PK) behavior in diverse patient populations. We evaluated the impact of mucositis on the oral isavuconazole exposure using population PK modeling. This...

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Publicat a:Antimicrob Agents Chemother
Autors principals: Kovanda, Laura L., Marty, Francisco M., Maertens, Johan, Desai, Amit V., Lademacher, Christopher, Engelhardt, Marc, Lu, Qiaoyang, Hope, William W.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2017
Matèries:
Pharmacology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5444187/
https://ncbi.nlm.nih.gov/pubmed/28289034
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00101-17
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