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Impact of Mucositis on Absorption and Systemic Drug Exposure of Isavuconazole

Isavuconazonium sulfate is the water-soluble prodrug of isavuconazole. Population analyses have demonstrated relatively predictable pharmacokinetic (PK) behavior in diverse patient populations. We evaluated the impact of mucositis on the oral isavuconazole exposure using population PK modeling. This...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Kovanda, Laura L., Marty, Francisco M., Maertens, Johan, Desai, Amit V., Lademacher, Christopher, Engelhardt, Marc, Lu, Qiaoyang, Hope, William W.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2017
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5444187/
https://ncbi.nlm.nih.gov/pubmed/28289034
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00101-17
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