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Loss of Methyltransferase Function and Increased Efflux Activity Leads to Doxycycline Resistance in Burkholderia pseudomallei

The soil-dwelling bacterium Burkholderia pseudomallei is the causative agent of the potentially fatal disease melioidosis. The lack of a vaccine toward B. pseudomallei means that melioidosis treatment relies on prolonged antibiotic therapy, which can last up to 6 months in duration or longer. Due to...

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Библиографические подробности
Опубликовано в: :Antimicrob Agents Chemother
Главные авторы: Webb, Jessica R., Price, Erin P., Currie, Bart J., Sarovich, Derek S.
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Microbiology 2017
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5444123/
https://ncbi.nlm.nih.gov/pubmed/28348161
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00268-17
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