Opposing effects of prostaglandin E(2) receptors EP3 and EP4 on mouse and human β-cell survival and proliferation

OBJECTIVE: Hyperglycemia and systemic inflammation, hallmarks of Type 2 Diabetes (T2D), can induce the production of the inflammatory signaling molecule Prostaglandin E(2) (PGE(2)) in islets. The effects of PGE(2) are mediated by its four receptors, E-Prostanoid Receptors 1-4 (EP1-4). EP3 and EP4 pl...

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Detalhes bibliográficos
Publicado no:Mol Metab
Main Authors: Carboneau, Bethany A., Allan, Jack A., Townsend, Shannon E., Kimple, Michelle E., Breyer, Richard M., Gannon, Maureen
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2017
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5444094/
https://ncbi.nlm.nih.gov/pubmed/28580285
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molmet.2017.04.002
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