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Opposing effects of prostaglandin E(2) receptors EP3 and EP4 on mouse and human β-cell survival and proliferation
OBJECTIVE: Hyperglycemia and systemic inflammation, hallmarks of Type 2 Diabetes (T2D), can induce the production of the inflammatory signaling molecule Prostaglandin E(2) (PGE(2)) in islets. The effects of PGE(2) are mediated by its four receptors, E-Prostanoid Receptors 1-4 (EP1-4). EP3 and EP4 pl...
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| 出版年: | Mol Metab |
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| 主要な著者: | , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Elsevier
2017
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| 主題: | |
| オンライン・アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5444094/ https://ncbi.nlm.nih.gov/pubmed/28580285 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molmet.2017.04.002 |
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