Membrane protein contact and structure prediction using co-evolution in conjunction with machine learning

De novo membrane protein structure prediction is limited to small proteins due to the conformational search space quickly expanding with length. Long-range contacts (24+ amino acid separation)–residue positions distant in sequence, but in close proximity in the structure, are arguably the most effec...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:PLoS One
Prif Awduron: Teixeira, Pedro L., Mendenhall, Jeff L., Heinze, Sten, Weiner, Brian, Skwark, Marcin J., Meiler, Jens
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Public Library of Science 2017
Pynciau:
Research Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5443516/
https://ncbi.nlm.nih.gov/pubmed/28542325
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0177866
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