ESCRT-III acts downstream of MLKL to regulate necroptotic cell death and its consequences

The activation of Mixed Lineage Kinase-Like (MLKL) by Receptor Interacting Protein Kinase-3 (RIPK3) results in plasma membrane (PM) disruption and a form of regulated necrosis, called necroptosis. Here we show that during necroptosis, MLKL-dependent calcium (Ca(++)) influx and phosphatidylserine (PS...

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Detalhes bibliográficos
Publicado no:Cell
Main Authors: Gong, Yi-Nan, Guy, Cliff, Olauson, Hannes, Becker, Jan Ulrich, Yang, Mao, Fitzgerald, Patrick, Linkermann, Andreas, Green, Douglas R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5443414/
https://ncbi.nlm.nih.gov/pubmed/28388412
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2017.03.020
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