Soluble Epoxide Hydrolase Pharmacological Inhibition Decreases Alveolar Bone Loss by Modulating Host Inflammatory Response, RANK-Related Signaling, Endoplasmic Reticulum Stress, and Apoptosis

Epoxyeicosatrienoic acids (EETs), metabolites of arachidonic acid derived from the cytochrome P450 enzymes, are mainly metabolized by soluble epoxide hydrolase (sEH) to their corresponding diols. EETs but not their diols, have anti-inflammatory properties, and inhibition of sEH might provide protect...

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Detalhes bibliográficos
Publicado no:J Pharmacol Exp Ther
Main Authors: Trindade-da-Silva, Carlos Antonio, Bettaieb, Ahmed, Napimoga, Marcelo Henrique, Lee, Kin Sing Stephen, Inceoglu, Bora, Ueira-Vieira, Carlos, Bruun, Donald, Goswami, Sumanta Kumar, Haj, Fawaz G., Hammock, Bruce D.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2017
Assuntos:
Drug Discovery and Translational Medicine
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5443319/
https://ncbi.nlm.nih.gov/pubmed/28356494
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.116.238113
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