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Inhibition of cardiac myofibroblast formation and collagen synthesis by activation and overexpression of adenylyl cyclase

Transformation of fibroblasts to myofibroblasts, characterized by expression of α-smooth muscle actin (α-SMA) and production of extracellular matrix (ECM) components, is a key event in connective tissue remodeling. Approaches to inhibit this transformation are needed in tissues, such as the heart, w...

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Detalhes bibliográficos
Main Authors: Swaney, James S., Roth, David M., Olson, Erik R., Naugle, Jennifer E., Meszaros, J. Gary, Insel, Paul A.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2005
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC544320/
https://ncbi.nlm.nih.gov/pubmed/15625103
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0408704102
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