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Hereditary persistence of α-fetoprotein and H19 expression in liver of BALB/cJ mice is due to a retrovirus insertion in the Zhx2 gene

The α-fetoprotein (AFP) and H19 genes are transcribed at high levels in the mammalian fetal liver but are rapidly repressed postnatally. This repression in the liver is controlled, at least in part, by the Afr1 gene. Afr1 was defined >25 years ago when BALB/cJ mice were found to have 5- to 20-fol...

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Autori principali: Perincheri, Sudhir, Dingle, R. W. Cameron, Peterson, Martha L., Spear, Brett T.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2005
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC544306/
https://ncbi.nlm.nih.gov/pubmed/15626755
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0408555102
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