Multilevel genomics of colorectal cancers with microsatellite instability—clinical impact of JAK1 mutations and consensus molecular subtype 1

BACKGROUND: Approximately 15% of primary colorectal cancers have DNA mismatch repair deficiency, causing a complex genome with thousands of small mutations—the microsatellite instability (MSI) phenotype. We investigated molecular heterogeneity and tumor immunogenicity in relation to clinical endpoin...

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Vydáno v:Genome Med
Hlavní autoři: Sveen, Anita, Johannessen, Bjarne, Tengs, Torstein, Danielsen, Stine A., Eilertsen, Ina A., Lind, Guro E., Berg, Kaja C. G., Leithe, Edward, Meza-Zepeda, Leonardo A., Domingo, Enric, Myklebost, Ola, Kerr, David, Tomlinson, Ian, Nesbakken, Arild, Skotheim, Rolf I., Lothe, Ragnhild A.
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2017
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5442873/
https://ncbi.nlm.nih.gov/pubmed/28539123
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13073-017-0434-0
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