Multilevel genomics of colorectal cancers with microsatellite instability—clinical impact of JAK1 mutations and consensus molecular subtype 1

BACKGROUND: Approximately 15% of primary colorectal cancers have DNA mismatch repair deficiency, causing a complex genome with thousands of small mutations—the microsatellite instability (MSI) phenotype. We investigated molecular heterogeneity and tumor immunogenicity in relation to clinical endpoin...

Description complète

Enregistré dans:
Détails bibliographiques
Publié dans:Genome Med
Auteurs principaux: Sveen, Anita, Johannessen, Bjarne, Tengs, Torstein, Danielsen, Stine A., Eilertsen, Ina A., Lind, Guro E., Berg, Kaja C. G., Leithe, Edward, Meza-Zepeda, Leonardo A., Domingo, Enric, Myklebost, Ola, Kerr, David, Tomlinson, Ian, Nesbakken, Arild, Skotheim, Rolf I., Lothe, Ragnhild A.
Format: Artigo
Langue:Inglês
Publié: BioMed Central 2017
Sujets:
Research
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5442873/
https://ncbi.nlm.nih.gov/pubmed/28539123
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13073-017-0434-0
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires