Early Immune Regulatory Changes in a Primary Controlled Human Plasmodium vivax Infection: CD1c(+) Myeloid Dendritic Cell Maturation Arrest, Induction of the Kynurenine Pathway, and Regulatory T Cell Activation

Plasmodium vivax malaria remains a major public health problem. The requirements for acquisition of protective immunity to the species are not clear. Dendritic cells (DC) are essential for immune cell priming but also perform immune regulatory functions, along with regulatory T cells (Treg). An impo...

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Veröffentlicht in:Infect Immun
Hauptverfasser: Woodberry, Tonia, Loughland, Jessica R., Minigo, Gabriela, Burel, Julie G., Amante, Fiona H., Piera, Kim A., McNeil, Yvette, Yeo, Tsin W., Good, Michael F., Doolan, Denise L., Engwerda, Christian R., McCarthy, James S., Anstey, Nicholas M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2017
Schlagworte:
Host Response and Inflammation
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5442628/
https://ncbi.nlm.nih.gov/pubmed/28320838
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00986-16
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