TAPBPR bridges UDP-glucose:glycoprotein glucosyltransferase 1 onto MHC class I to provide quality control in the antigen presentation pathway

Recently, we revealed that TAPBPR is a peptide exchange catalyst that is important for optimal peptide selection by MHC class I molecules. Here, we asked whether any other co-factors associate with TAPBPR, which would explain its effect on peptide selection. We identify an interaction between TAPBPR...

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Bibliografske podrobnosti
izdano v:eLife
Main Authors: Neerincx, Andreas, Hermann, Clemens, Antrobus, Robin, van Hateren, Andy, Cao, Huan, Trautwein, Nico, Stevanović, Stefan, Elliott, Tim, Deane, Janet E, Boyle, Louise H
Format: Artigo
Jezik:Inglês
Izdano: eLife Sciences Publications, Ltd 2017
Teme:
Cell Biology
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5441866/
https://ncbi.nlm.nih.gov/pubmed/28425917
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.23049
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