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Genetic rescue models refute nonautonomous rod cell death in retinitis pigmentosa

Retinitis pigmentosa (RP) is an inherited neurodegenerative disease, in which the death of mutant rod photoreceptors leads secondarily to the non-cell autonomous death of cone photoreceptors. Gene therapy is a promising treatment strategy. Unfortunately, current methods of gene delivery treat only a...

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Bibliographische Detailangaben
Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Koch, Susanne F., Duong, Jimmy K., Hsu, Chun-Wei, Tsai, Yi-Ting, Lin, Chyuan-Sheng, Wahl-Schott, Christian A., Tsang, Stephen H.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2017
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5441755/
https://ncbi.nlm.nih.gov/pubmed/28468800
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1615394114
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