Biliary epithelial injury-induced regenerative response by IL-33 promotes cholangiocarcinogenesis from peribiliary glands

The carcinogenic mechanism of extrahepatic cholangiocarcinoma (ECC) is unclear, due at least in part to the lack of an appropriate mouse model. Because human studies have reported frequent genetic alterations in the Ras- and TGFβ/SMAD-signaling pathways in ECC, mice with tamoxifen-inducible, duct-ce...

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Dettagli Bibliografici
Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Nakagawa, Hayato, Suzuki, Nobumi, Hirata, Yoshihiro, Hikiba, Yohko, Hayakawa, Yoku, Kinoshita, Hiroto, Ihara, Sozaburo, Uchino, Koji, Nishikawa, Yuji, Ijichi, Hideaki, Otsuka, Motoyuki, Arita, Junichi, Sakamoto, Yoshihiro, Hasegawa, Kiyoshi, Kokudo, Norihiro, Tateishi, Keisuke, Koike, Kazuhiko
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2017
Soggetti:
PNAS Plus
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5441746/
https://ncbi.nlm.nih.gov/pubmed/28439013
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1619416114
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