Biliary epithelial injury-induced regenerative response by IL-33 promotes cholangiocarcinogenesis from peribiliary glands

The carcinogenic mechanism of extrahepatic cholangiocarcinoma (ECC) is unclear, due at least in part to the lack of an appropriate mouse model. Because human studies have reported frequent genetic alterations in the Ras- and TGFβ/SMAD-signaling pathways in ECC, mice with tamoxifen-inducible, duct-ce...

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發表在:Proc Natl Acad Sci U S A
Main Authors: Nakagawa, Hayato, Suzuki, Nobumi, Hirata, Yoshihiro, Hikiba, Yohko, Hayakawa, Yoku, Kinoshita, Hiroto, Ihara, Sozaburo, Uchino, Koji, Nishikawa, Yuji, Ijichi, Hideaki, Otsuka, Motoyuki, Arita, Junichi, Sakamoto, Yoshihiro, Hasegawa, Kiyoshi, Kokudo, Norihiro, Tateishi, Keisuke, Koike, Kazuhiko
格式: Artigo
語言:Inglês
出版: National Academy of Sciences 2017
主題:
PNAS Plus
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5441746/
https://ncbi.nlm.nih.gov/pubmed/28439013
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1619416114
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