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Murine model indicates 22q11.2 signaling adaptor CRKL is a dosage-sensitive regulator of genitourinary development

The spectrum of congenital anomalies affecting either the upper tract (kidneys and ureters) or lower tract (reproductive organs) of the genitourinary (GU) system are fundamentally linked by the developmental origin of multiple GU tissues, including the kidneys, gonads, and reproductive ductal system...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Haller, Meade, Mo, Qianxing, Imamoto, Akira, Lamb, Dolores J.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5441740/
https://ncbi.nlm.nih.gov/pubmed/28439006
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1619523114
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