GPR40 partial agonist MK-2305 lower fasting glucose in the Goto Kakizaki rat via suppression of endogenous glucose production

GPR40 (FFA1) is a fatty acid receptor whose activation results in potent glucose lowering and insulinotropic effects in vivo. Several reports illustrate that GPR40 agonists exert glucose lowering in diabetic humans. To assess the mechanisms by which GPR40 partial agonists improve glucose homeostasis...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Miller, Corin, Pachanski, Michele J., Kirkland, Melissa E., Kosinski, Daniel T., Mane, Joel, Bunzel, Michelle, Cao, Jin, Souza, Sarah, Thomas-Fowlkes, Brande, Di Salvo, Jerry, Weinglass, Adam B., Li, Xiaoyan, Myers, Robert W., Knagge, Kevin, Carrington, Paul E., Hagmann, William K., Trujillo, Maria E.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5441580/
https://ncbi.nlm.nih.gov/pubmed/28542610
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0176182
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