G→A Hypermutation in Protease and Reverse Transcriptase Regions of Human Immunodeficiency Virus Type 1 Residing in Resting CD4(+) T Cells In Vivo

In vitro studies have shown that the host cytidine deaminase APOBEC3G causes lethal hypermutation in human immunodeficiency virus type 1 reverse transcripts unless its incorporation into virions is blocked by Vif. By examining stably archived sequences in resting CD4(+) T cells, we show that hypermu...

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Argitaratua izan da:	J Virol
Egile Nagusiak:	Kieffer, Tara L., Kwon, Patty, Nettles, Richard E., Han, Yefei, Ray, Stuart C., Siliciano, Robert F.
Formatua:	Artigo
Hizkuntza:	Inglês
Argitaratua:	American Society for Microbiology (ASM) 2005
Gaiak:	Replication
Sarrera elektronikoa:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC544145/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15650227/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JVI.79.3.1975-1980.2005
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