G→A Hypermutation in Protease and Reverse Transcriptase Regions of Human Immunodeficiency Virus Type 1 Residing in Resting CD4(+) T Cells In Vivo

In vitro studies have shown that the host cytidine deaminase APOBEC3G causes lethal hypermutation in human immunodeficiency virus type 1 reverse transcripts unless its incorporation into virions is blocked by Vif. By examining stably archived sequences in resting CD4(+) T cells, we show that hypermu...

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Detalhes bibliográficos
Main Authors: Kieffer, Tara L., Kwon, Patty, Nettles, Richard E., Han, Yefei, Ray, Stuart C., Siliciano, Robert F.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2005
Assuntos:
Replication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC544145/
https://ncbi.nlm.nih.gov/pubmed/15650227
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.79.3.1975-1980.2005
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