Elimination of Retroviral Infectivity by N-Ethylmaleimide with Preservation of Functional Envelope Glycoproteins

The zinc finger motifs in retroviral nucleocapsid (NC) proteins are essential for viral replication. Disruption of these Cys-X(2)-Cys-X(4)-His-X(4)-Cys zinc-binding structures eliminates infectivity. To determine if N-ethylmaleimide (NEM) can inactivate human immunodeficiency virus type 1 (HIV-1) or...

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Dades bibliogràfiques
Autors principals: Morcock, David R., Thomas, James A., Gagliardi, Tracy D., Gorelick, Robert J., Roser, J. David, Chertova, Elena N., Bess, Julian W., Ott, David E., Sattentau, Quentin J., Frank, Ines, Pope, Melissa, Lifson, Jeffrey D., Henderson, Louis E., Crise, Bruce J.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2005
Matèries:
Vaccines and Antiviral Agents
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC544125/
https://ncbi.nlm.nih.gov/pubmed/15650179
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.79.3.1533-1542.2005
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