Elimination of Retroviral Infectivity by N-Ethylmaleimide with Preservation of Functional Envelope Glycoproteins

The zinc finger motifs in retroviral nucleocapsid (NC) proteins are essential for viral replication. Disruption of these Cys-X(2)-Cys-X(4)-His-X(4)-Cys zinc-binding structures eliminates infectivity. To determine if N-ethylmaleimide (NEM) can inactivate human immunodeficiency virus type 1 (HIV-1) or...

Descrición completa

Gardado en:
Detalles Bibliográficos
Main Authors: Morcock, David R., Thomas, James A., Gagliardi, Tracy D., Gorelick, Robert J., Roser, J. David, Chertova, Elena N., Bess, Julian W., Ott, David E., Sattentau, Quentin J., Frank, Ines, Pope, Melissa, Lifson, Jeffrey D., Henderson, Louis E., Crise, Bruce J.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2005
Assuntos:
Vaccines and Antiviral Agents
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC544125/
https://ncbi.nlm.nih.gov/pubmed/15650179
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.79.3.1533-1542.2005
Tags: Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!

Títulos similares