Elimination of Retroviral Infectivity by N-Ethylmaleimide with Preservation of Functional Envelope Glycoproteins

The zinc finger motifs in retroviral nucleocapsid (NC) proteins are essential for viral replication. Disruption of these Cys-X(2)-Cys-X(4)-His-X(4)-Cys zinc-binding structures eliminates infectivity. To determine if N-ethylmaleimide (NEM) can inactivate human immunodeficiency virus type 1 (HIV-1) or...

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Detalhes bibliográficos
Main Authors: Morcock, David R., Thomas, James A., Gagliardi, Tracy D., Gorelick, Robert J., Roser, J. David, Chertova, Elena N., Bess, Julian W., Ott, David E., Sattentau, Quentin J., Frank, Ines, Pope, Melissa, Lifson, Jeffrey D., Henderson, Louis E., Crise, Bruce J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2005
Assuntos:
Vaccines and Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC544125/
https://ncbi.nlm.nih.gov/pubmed/15650179
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.79.3.1533-1542.2005
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