Elimination of Retroviral Infectivity by N-Ethylmaleimide with Preservation of Functional Envelope Glycoproteins

The zinc finger motifs in retroviral nucleocapsid (NC) proteins are essential for viral replication. Disruption of these Cys-X(2)-Cys-X(4)-His-X(4)-Cys zinc-binding structures eliminates infectivity. To determine if N-ethylmaleimide (NEM) can inactivate human immunodeficiency virus type 1 (HIV-1) or...

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Autores principales: Morcock, David R., Thomas, James A., Gagliardi, Tracy D., Gorelick, Robert J., Roser, J. David, Chertova, Elena N., Bess, Julian W., Ott, David E., Sattentau, Quentin J., Frank, Ines, Pope, Melissa, Lifson, Jeffrey D., Henderson, Louis E., Crise, Bruce J.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2005
Materias:
Vaccines and Antiviral Agents
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC544125/
https://ncbi.nlm.nih.gov/pubmed/15650179
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.79.3.1533-1542.2005
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