Mutant KRAS promotes malignant pleural effusion formation

Malignant pleural effusion (MPE) is the lethal consequence of various human cancers metastatic to the pleural cavity. However, the mechanisms responsible for the development of MPE are still obscure. Here we show that mutant KRAS is important for MPE induction in mice. Pleural disseminated, mutant K...

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Veröffentlicht in:Nat Commun
Hauptverfasser: Αgalioti, Theodora, Giannou, Anastasios D., Krontira, Anthi C., Kanellakis, Nikolaos I., Kati, Danai, Vreka, Malamati, Pepe, Mario, Spella, Μagda, Lilis, Ioannis, Zazara, Dimitra E., Nikolouli, Eirini, Spiropoulou, Nikolitsa, Papadakis, Andreas, Papadia, Konstantina, Voulgaridis, Apostolos, Harokopos, Vaggelis, Stamou, Panagiota, Meiners, Silke, Eickelberg, Oliver, Snyder, Linda A., Antimisiaris, Sophia G., Kardamakis, Dimitrios, Psallidas, Ioannis, Μarazioti, Antonia, Stathopoulos, Georgios T.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2017
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5440809/
https://ncbi.nlm.nih.gov/pubmed/28508873
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms15205
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