Mutant KRAS promotes malignant pleural effusion formation

Malignant pleural effusion (MPE) is the lethal consequence of various human cancers metastatic to the pleural cavity. However, the mechanisms responsible for the development of MPE are still obscure. Here we show that mutant KRAS is important for MPE induction in mice. Pleural disseminated, mutant K...

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Udgivet i:Nat Commun
Main Authors: Αgalioti, Theodora, Giannou, Anastasios D., Krontira, Anthi C., Kanellakis, Nikolaos I., Kati, Danai, Vreka, Malamati, Pepe, Mario, Spella, Μagda, Lilis, Ioannis, Zazara, Dimitra E., Nikolouli, Eirini, Spiropoulou, Nikolitsa, Papadakis, Andreas, Papadia, Konstantina, Voulgaridis, Apostolos, Harokopos, Vaggelis, Stamou, Panagiota, Meiners, Silke, Eickelberg, Oliver, Snyder, Linda A., Antimisiaris, Sophia G., Kardamakis, Dimitrios, Psallidas, Ioannis, Μarazioti, Antonia, Stathopoulos, Georgios T.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5440809/
https://ncbi.nlm.nih.gov/pubmed/28508873
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms15205
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