Mutant KRAS promotes malignant pleural effusion formation

Malignant pleural effusion (MPE) is the lethal consequence of various human cancers metastatic to the pleural cavity. However, the mechanisms responsible for the development of MPE are still obscure. Here we show that mutant KRAS is important for MPE induction in mice. Pleural disseminated, mutant K...

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Pubblicato in:Nat Commun
Autori principali: Αgalioti, Theodora, Giannou, Anastasios D., Krontira, Anthi C., Kanellakis, Nikolaos I., Kati, Danai, Vreka, Malamati, Pepe, Mario, Spella, Μagda, Lilis, Ioannis, Zazara, Dimitra E., Nikolouli, Eirini, Spiropoulou, Nikolitsa, Papadakis, Andreas, Papadia, Konstantina, Voulgaridis, Apostolos, Harokopos, Vaggelis, Stamou, Panagiota, Meiners, Silke, Eickelberg, Oliver, Snyder, Linda A., Antimisiaris, Sophia G., Kardamakis, Dimitrios, Psallidas, Ioannis, Μarazioti, Antonia, Stathopoulos, Georgios T.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5440809/
https://ncbi.nlm.nih.gov/pubmed/28508873
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms15205
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