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Legionella effector Lpg1137 shuts down ER-mitochondria communication through cleavage of syntaxin 17

During infection of macrophages, the pathogenic bacterium Legionella pneumophila secretes effector proteins that induce the conversion of the plasma membrane-derived vacuole into an endoplasmic reticulum (ER)-like replicative vacuole. These ER-like vacuoles are ultimately fused with the ER, where th...

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Vydáno v:Nat Commun
Hlavní autoři: Arasaki, Kohei, Mikami, Yumi, Shames, Stephanie R., Inoue, Hiroki, Wakana, Yuichi, Tagaya, Mitsuo
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2017
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5440676/
https://ncbi.nlm.nih.gov/pubmed/28504273
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms15406
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