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Microtubule-binding drugs offset tau sequestration by stabilizing microtubules and reversing fast axonal transport deficits in a tauopathy model

We tested the hypothesis that microtubule (MT)-binding drugs could be therapeutically beneficial in tauopathies by functionally substituting for the MT-binding protein tau, which is sequestered into inclusions of human tauopathies and transgenic mouse models thereof. Transgenic mice were treated for...

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Publicat a:Proc Natl Acad Sci U S A
Autors principals: Zhang, Bin, Maiti, Arpita, Shively, Sharon, Lakhani, Fara, McDonald-Jones, Gaye, Bruce, Jennifer, Lee, Edward B., Xie, Sharon X., Joyce, Sonali, Li, Chi, Toleikis, Philip M., Lee, Virginia M.-Y., Trojanowski, John Q.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2004
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC544048/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15615853/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0406361102
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