Inhibition of MT1-MMP proteolytic function and ERK1/2 signalling influences cell migration and invasion through changes in MMP-2 and MMP-9 levels

Membrane type-1 matrix metalloproteinase (MT1-MMP, MMP-14) is a unique protease that cleaves extracellular proteins, activates proMMPs, and initiates intracellular signalling. MCF-7 cells are non-invasive and deficient in MT1-MMP, MMP-2, and MMP-9 expression. We created an MCF-7 cell line (C2) that...

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Veröffentlicht in:J Cell Commun Signal
Hauptverfasser: Cepeda, Mario A., Evered, Caitlin L., Pelling, Jacob J. H ., Damjanovski, Sashko
Format: Artigo
Sprache:Inglês
Veröffentlicht: Springer Netherlands 2017
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5440346/
https://ncbi.nlm.nih.gov/pubmed/28070797
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12079-016-0373-3
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