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Less is more: low expression of MT1-MMP is optimal to promote migration and tumourigenesis of breast cancer cells

BACKGROUND: Membrane Type-1 Matrix Metalloproteinase (MT1-MMP) is a multifunctional protease implicated in metastatic progression ostensibly due to its ability to degrade extracellular matrix (ECM) components and allow migration of cells through the basement membrane. Despite in vitro studies demons...

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Detalhes bibliográficos
Publicado no:Mol Cancer
Main Authors: Cepeda, Mario A., Pelling, Jacob J. H., Evered, Caitlin L., Williams, Karla C., Freedman, Zoey, Stan, Ioana, Willson, Jessica A., Leong, Hon S., Damjanovski, Sashko
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2016
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5070195/
https://ncbi.nlm.nih.gov/pubmed/27756325
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12943-016-0547-x
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