PCNA ubiquitylation ensures timely completion of unperturbed DNA replication in fission yeast

PCNA ubiquitylation on lysine 164 is required for DNA damage tolerance. In many organisms PCNA is also ubiquitylated in unchallenged S phase but the significance of this has not been established. Using Schizosaccharomyces pombe, we demonstrate that lysine 164 ubiquitylation of PCNA contributes to ef...

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Bibliographic Details
Published in:	PLoS Genet
Main Authors:	Daigaku, Yasukazu, Etheridge, Thomas J., Nakazawa, Yuka, Nakayama, Mayumi, Watson, Adam T., Miyabe, Izumi, Ogi, Tomoo, Osborne, Mark A., Carr, Antony M.
Format:	Artigo
Language:	Inglês
Published:	Public Library of Science 2017
Subjects:	Research Article
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC5440044/ https://ncbi.nlm.nih.gov/pubmed/28481910 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1006789
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PCNA ubiquitylation ensures timely completion of unperturbed DNA replication in fission yeast

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